What to expect when using Progesterone Cream for the first time


Vitamin D3 is vital as it is connection to every single cell and its formation in our bodies. A deficiency reduces the benefits of progesterone, see here, here and here.If you are deficient it will take progesterone longer to work, and in most cases, it simply does not work.  It is so important to get your level up as per the link provided.  Please have a vitamin D3 test done.


It is most important that you understand and are aware of certain symptoms which may be experienced when using progesterone cream for the first time. 

I am often asked "what happens if I use too much" or "isn't that too much progesterone to use"?  The answer is, NOTHING and NO!  The more you use in the beginning, the better it is for you as it helps to avoid Estrogen Dominance symptoms caused by excess estrogen. The late Dr Kittie Dalton used to prescribe 2400mg per day successfully to those suffering from PND and psychotic like symptoms and 800mg for nausea. TBI sufferers are giving 1400mg per day.  NEVER use anything less than 100mg/3ml per day!  When first starting to use progesterone it is best to start on 200mg/6ml per day to help the body adjust, more maybe needed, it all depends on how much excess estrogen you have. Experiment, find a level that suits you and your symptoms.  Once progesterone has become the dominant hormone, you can slowly reduce the amount of cream.

Another question asked regularly is, "how long will it take before I notice a difference"?  That's a difficult question to answer, you have to understand that any natural product, no matter what it is, is not a 'quick fix' solution, things take time and patience is definitely needed.  Some people think that their symptoms will improve after only 2 to 3 days use, WRONG!  Positive results can be felt from 2 to 6 months, possibly longer. It is important to use the correct amount of progesterone according to your symptoms.  NEVER use less than 100mg/3ml per day if you are female, men can use less but again this depends on symptoms.  A higher dose is often needed to address a particular symptoms. If you use too little or stop using progesterone your symptoms, whatever they are, will return. While nothing less than 100mg/3ml per day is needed, it is best to use 200mg.6ml per day when first starting, adjusting to suit your symptoms.  Once progesterone has become dominant and you feel stable, can you reduce down to 100mg/3ml per day.  Please read How to use Progesterone Cream to find out the correct way of reducing the cream.  It should be used a minimum of twice a day as progesterone levels start to drop after 13 hours and the aim is to keep progesterone levels stable.  Some find using the cream 3 or 4 times a day works better for them, experiment to find out what suits you!

People react differently to certain things, what may cause you discomfort, will not to others.  You may experience 'adverse' symptoms often encountered by men and women if they have a naturally high level of estrogen or, in the case of women, who have been on HRT (hormone replacement therapy) or the Contraceptive Pill for any length of time and therefore have low progesterone levels. In some cases you may experience:

  • aches and pains in your joints
  • water retention
  • weight gain
  • heart palpitations or a tight chest
  • headaches
  • change in sleep pattern
  • hair loss

Please persevere with the progesterone cream, DO NOT stop using it as these uncomfortable symptoms will ease IF used correctly.  We are now getting reports from women using as much as 400mg/12ml in the beginning stating that it prevents them from experiencing these adverse symptoms otherwise known as ESTROGEN DOMINANCE symptoms.  If you find that 100mg/3ml - 200mg/6ml is not working for you, then increase until you find a level that suits you as already explained, then once you feel stable you can begin to slowly reduce down to a level that suits you. Those suffering from hot flushes and night sweats need to use 400-500mg per day for 5 - 6 days, more if symptoms are severe, it's the quickest way of getting rid of the hot flushes etc.  Once things improve you can slowly reduce.

Men can also experience estrogen dominance symptoms when first using progesterone, some even get 'man boobs' men however, do not need to use such high doses - 100mg/3ml reducing down to 2ml per day would be the correct dose for men unless he has a specific symptom like prostate problems.


How to Reduce Progesterone Cream

You can slowly start to reduce the amount of cream used once you feel stable enough to do so.  It is vital that this is done SLOWLY - if too much is reduce too soon, your symptoms will return. Should this happen, simply increase the amount of cream until you feel stable again and then try again by slowly reducing.  It is essential to reduce over a few weeks to prevent adverse symptoms returning.

How to Reduce - reduce by no more than 16-20mg at a time.  Stay on the reduced amount for a few days before reducing again. Continue reducing until you find a level that suits you.  Symptoms will return if you reduce by too much and too quickly.  Never reduce to less than 100mg/3ml per day as all adverse symptoms will return. 


As you use progesterone it will gradually become the dominant hormone which is what is needed.  As this happens symptoms begin to ease.

You are estrogen dominant if you experience some of the symptoms listed below.  Men also experience these symptoms apart from the obvious female problems.

  • aches and pains
  • anger
  • bleeding which comes either earlier or later than usual in your monthly cycle
  • bloating/weight gain due to water retention
  • breast tenderness
  • bruising
  • constipation
  • dizziness
  • headaches
  • heart palpitations
  • hot flushes
  • hypoglycaemia
  • increased appetite/cravings
  • irritation
  • migraines
  • mild depression
  • mood swings
  • muscle weakness
  • nausea
  • skin problems/acne/melasma
  • spotting
  • tiredness/chronic fatigue

Please follow these instructions when using progesterone cream for the first time.  The cream can be use anywhere and everywhere, all over your body including your face.  Insert it in the vagina at night as it is excellent for dryness and inflammation, even hair follicles absorb it well.  If you have an ache or a pain rub the cream on the painful area as progesterone is an excellent anti-inflammatory.  I have even used it on my tongue to see if it will help the burning sensation that I get from time to time and it does ease the burn.

Please note:  The information below showing quantities of progesterone cream are based on a concentration of 3.33% progesterone which is in a 2oz (60 gram) tube of Natpro cream containing 2000mg (2 grams) of progesterone.




  1. Menstruating - if a regular cycle is present, apply cream twice daily from ovulation for the next 14 days, bleeding should occur within a day or two.  The luteal phase is always 12 - 14 days in all women, any less and it is known as a 'defective luteal phase'.  Cycles vary from 21 days to 36 days.  For example in a 21 day cycle the cream should be used from day 8 for 14 days, if a 28 day cycle from day 15 for 14 days and if a 36 days cycle from day 22 for 14 days. Use 100-200mg/3-6ml per day, more maybe needed depending on how severe symptoms are.
  2. Peri or Post Menopausal, Hysterectomy, Oophorectomy, Pre-pubertal, Pubertal - if there is no cycle, or it is erratic use 100-200mg/3-6ml possibly more depending on how severe symptoms are EVERY DAY with no stopping.  Ignore any bleeding, spotting or clotting that may occur. There is no need to take a break as some suggest, although some women prefer to have one but they usually land up using it daily with no breaks. Also, if the cycle is erratic it is difficult to follow a cycle.
  3. Severe symptoms -  Hot Flushes use at least 400-500mg per day, this generally stops them.  It is best to apply the cream hourly.  Heavy, continual bleeding use 400-600mg per day for 1 to 3 months, ignoring the cycle.  When the bleeding has stopped, slowly reduce the cream until bleeding occurs again, then discontinue the cream for 14 days.  Then start using the cream again from day 15 for 14 days.  Over the coming months the natural cycle length will assert itself.  It is best to apply the cream hourly.  A multitude of bad symptoms use a minimum of 200mg/6ml per day following the cycle if there is one, more might be needed.  If symptoms return during the break, then continue applying the cream twice a day or more frequently until they resolve.  Once they have, then begin to follow your cycle again.




Use from 10 - 100mg/ 0.3 - 3ml per day.  It is best to use the cream twice a day.


Please read How to Use Progesterone Cream so that you fully understand how it works!!  You will also find a chart indicating how long a tube of Natpro will last you using different amounts and is show the teaspoon, mg and ml conversion.  The teaspoon used is a metric teaspoon which is 5ml.


If you do not follow the above instructions it will not work and you will think that  progesterone cream does not work which is totally untrue.


  • when your tube of Natpro is finished, please cut it open as there is usually quite a bit of cream left behind.  This cream is simply too valuable to throw away
  • progesterone cream is the best delivery method as 96% gets destroyed by the gut and liver if using oral progesterone - see here
  • use Natpro Progesterone cream as a facial moisturiser
  • it is EXCELLENT as an underarm deodorant
  • excellent on burns and insect bites etc
  • rub on any ache or pain as it is a good anti-inflammatory
    • insert in vagina at night to help with dryness and inflammation - you do NOT need to use estrogen for this



Before using progesterone cream for the first time, please read the link
on estrogen dominance